Search on: BUMETANIDE-SENSITIVE SODIUM-(POTASSIUM)-CHLORIDE COTRANSPORTER 2 
Descriptors Found: 1
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Descriptor English:   Solute Carrier Family 12, Member 1 
Descriptor Spanish:   Miembro 1 de la Familia de Transportadores de Soluto 12 
Descriptor Portuguese:   Membro 1 da Família 12 de Carreador de Soluto 
Synonyms English:   BSC1 Transport Protein
Bumetanide-Sensitive Sodium-(Potassium)-Chloride Cotransporter 2
Kidney-Specific Na-K-Cl Symporter
NKCC2 Cotransporter
NKCC2 Protein
SLC12A1 Cotransporter
SLC12A1 Protein
Cotransporter, NKCC2
Cotransporter, SLC12A1
Kidney Specific Na K Cl Symporter
Na-K-Cl Symporter, Kidney-Specific
Protein, BSC1 Transport
Protein, NKCC2
Protein, SLC12A1
Symporter, Kidney-Specific Na-K-Cl
Transport Protein, BSC1  
Tree Number:   D12.776.157.530.450.625.750.500
D12.776.157.530.937.750.500
D12.776.543.585.450.625.750.500
D12.776.543.585.937.875.500
Definition English:   Na-K-Cl transporter in the ASCENDING LIMB OF LOOP OF HENLE. It mediates active reabsorption of sodium chloride and is inhibited by LOOP DIURETICS such as FUROSEMIDE; and BUMETANIDE. Mutations in the gene encoding SLC12A1 are associated with a BARTTER SYNDROME. 
See Related English:   Bartter Syndrome
 
History Note English:   2014 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   55323 
Unique Identifier:   D064466 

Occurrence in VHL: 		 

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